![](/CAS/GIF/4703-33-7.gif)
N-(P-TOLUENESULFONYL)-D,L-METHIONINE synthesis
1synthesis methods
- Product Name:N-(P-TOLUENESULFONYL)-D,L-METHIONINE
- CAS Number:4703-33-7
- Molecular formula:C12H17NO4S2
- Molecular Weight:303.4
Yield:4703-33-7 70.3%
Reaction Conditions:
Stage #1: DL-methioninewith sodium carbonate in water at -5;Green chemistry;
Stage #2: p-toluenesulfonyl chloride in water at -5 - 20; for 5 h;Green chemistry;
Stage #3: with hydrogenchloride in water at 20; for 12 h;Green chemistry;
References:
Egbujor, Melford C.;Okoro, Uchechukwu C.;Okafor, Sunday N.;Amasiatu, Ifeanyi S.;Amadi, Ugochukwu B.;Egwuatu, Pius I. [International Journal of Research in Pharmaceutical Sciences,2020,vol. 11,# 4,p. 5357 - 5366]