![](/CAS/GIF/23056-29-3.gif)
N-phenylpiperidin-4-amine synthesis
- Product Name:N-phenylpiperidin-4-amine
- CAS Number:23056-29-3
- Molecular formula:C11H16N2
- Molecular Weight:176.26
![1-N-Boc-4-(Phenylamino)piperidine](/CAS/GIF/125541-22-2.gif)
125541-22-2
160 suppliers
$31.00/1g
![N-phenylpiperidin-4-amine](/CAS/GIF/23056-29-3.gif)
23056-29-3
12 suppliers
$217.00/5g
Yield:23056-29-3 100%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 1 h;
Steps:
Reagents and conditions: (a) NaBH(OAc)3, AcOH, aniline, DCE, overnight, rt, (yield 84%); (b) TFA, DCM, lh, rt, quant; (c) toluene, 2h, rt, (general yields 5- 23%). In Scheme 8, the reductive amination of aniline with 1 -boc-4-piperidone followed by deprotection in acidic condition afforded compound 6 which was reacted with appropriate isocyanates or isothiocyanates to produce the 4- anilinopiperidine series 7a-g.
References:
ROBERTS, Edward;MITTAPALLI, Gopi Kumar;VELLUCCI, Danielle;YANG, Jun;GUERRERO, Miguel;URBANO, Mariangela;ROSEN, Hugh WO2014/116684, 2014, A1 Location in patent:Page/Page column 251
![N-(1-Carbethoxypiperidin-4-yl)Aniline](/CAS/GIF/116512-92-6.gif)
116512-92-6
5 suppliers
inquiry
![N-phenylpiperidin-4-amine](/CAS/GIF/23056-29-3.gif)
23056-29-3
12 suppliers
$217.00/5g
![4-oxopiperidinium chloride](/CAS/GIF/41979-39-9.gif)
41979-39-9
117 suppliers
$15.00/10mg
![Aniline](/CAS/GIF/62-53-3.gif)
62-53-3
637 suppliers
$10.00/1g
![N-phenylpiperidin-4-amine](/CAS/GIF/23056-29-3.gif)
23056-29-3
12 suppliers
$217.00/5g
![N-(tert-Butoxycarbonyl)-4-piperidone](/CAS/GIF/79099-07-3.gif)
79099-07-3
543 suppliers
$5.00/5g
![N-phenylpiperidin-4-amine](/CAS/GIF/23056-29-3.gif)
23056-29-3
12 suppliers
$217.00/5g
![N-Carbethoxy-4-piperidone](/CAS/GIF/29976-53-2.gif)
29976-53-2
394 suppliers
$5.00/5g
![N-phenylpiperidin-4-amine](/CAS/GIF/23056-29-3.gif)
23056-29-3
12 suppliers
$217.00/5g