N-(tert-Butoxycarbonyl)-2-aminoacetonitrile synthesis
- Product Name:N-(tert-Butoxycarbonyl)-2-aminoacetonitrile
- CAS Number:85363-04-8
- Molecular formula:C7H12N2O2
- Molecular Weight:156.18
24424-99-5
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85363-04-8
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Yield: 97.1%
Reaction Conditions:
with triethylamine in dichloromethane;water at 20; for 15 h;Cooling with ice;
Steps:
2 Example 2
Add the raw materials aminoacetonitrile hydrochloride (65g, 0.70mol), dichloromethane (650mL) to the reaction flask, stir, add triethylamine (213.27g, 2.1mol, 3eq), cool down in an ice water bath,Add Boc anhydride (229.9, 1.1 mol, 1.5 eq) dropwise, add water (650 mL), separate and wash with water after stirring at room temperature for 15 hours. After drying the organic phase with anhydrous sodium sulfate, filter and concentrate to obtain compound B2 ( 106.5g, 97.1%)
References:
Zhejiang Jingxin Pharmaceutical Co., Ltd.;Shanghai Jingxin Bio-pharmaceutical Co., Ltd.;Guo Sigen;Wu Maojiang;Xu Miaohuan;Xu Hui;Song Liqiang;Li Fengjie;Liu Yunlong CN111620834, 2020, A Location in patent:Paragraph 0052-0056
24424-99-5
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151-63-3
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85363-04-8
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35150-09-5
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85363-04-8
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22821-76-7
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85363-04-8
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172876-96-9
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85363-04-8
101 suppliers
$6.00/250mg