ChemicalBook CAS DataBase List naphthalene-1-sulfonamide(WXC08815)

naphthalene-1-sulfonamide(WXC08815) synthesis

10synthesis methods

Product Name:naphthalene-1-sulfonamide(WXC08815)
CAS Number:606-25-7
Molecular formula:C10H9NO2S
Molecular Weight:207.25

85-46-1
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Yield:606-25-7 96.7%

Reaction Conditions:

with ammonium hydroxide in acetone at 0;

Steps:

1 Preparation of 1-naphthalenesulfonamide (Compound 2)

1-naphthalenesulfonyl chloride (5 g, 21.9 mmol) was added to a 1 L round bottom flask containing 200 ml of acetone, stirred, In the ice bath drop 240ml 0°C of ammonia, dripping finished, the thin layer tracking test reaction, the reaction is completed, Vacuum distillation of organic solvents and ammonia decomposition of ammonia, precipitation of solid, filtration, vacuum drying, To give 1-naphthalenesulfonamide (4.35 g, yield 96.7%). The compound was used in the next step without further purification. The experimental data are as follows:

References:

CN106946810,2017,A Location in patent:Paragraph 0033-0036