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Necopidem synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / methanol / 20 h / 65 °C
2: sodium tetrahydroborate / methanol / 0 - 20 °C
3: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

References:

Wang, Honggen;Wang, Yong;Liang, Dongdong;Liu, Lanying;Zhang, Jiancun;Zhu, Qiang [Angewandte Chemie - International Edition,2011,vol. 50,# 25,p. 5678 - 5681]

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