Nilotinib genotoxic impurity 3 synthesis

6synthesis methods

Product Name:Nilotinib genotoxic impurity 3
CAS Number:915711-42-1
Molecular formula:C19H17F3N4O
Molecular Weight:374.36

1449570-25-5
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915711-42-1
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Yield:915711-42-1 80%

Reaction Conditions:

Stage #1: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-nitrobenzamide hydrochloridewith tin(ll) chloride in methanol at 10;Reflux;
Stage #2: with sodium hydroxide in methanol;water at 10 - 15; for 2 h;

References:

Amala;Bhujanga Rao;Sreenivas;Dubey [Asian Journal of Chemistry,2013,vol. 25,# 8,p. 4599 - 4602]

1157857-29-8
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References

96-98-0
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915711-42-1
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10397-30-5
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641571-11-1 Synthesis

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

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References

Nilotinib genotoxic impurity 3 Related Search:

3-Amino-4-methylbenzoic acid Methyl 3-amino-4-methylbenzoate 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 3-(4-Methylimidazol-1-yl)-5-trifluoromethylbenzoic acid 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide 3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline