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ChemicalBook CAS DataBase List NORMEPERIDINE
24465-45-0

NORMEPERIDINE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C
1.2: phenyl halide / 6 h / -78 - 20 °C
2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

References:

Axford, Lorraine C.;Agarwal, Piyush K.;Anderson, Kelly H.;Andrau, Laura N.;Atherall, John;Barker, Stephanie;Bennett, James M.;Blair, Michael;Collins, Ian;Czaplewski, Lloyd G.;Davies, David T.;Gannon, Carlie T.;Kumar, Dushyant;Lancett, Paul;Logan, Alastair;Lunniss, Christopher J.;Mitchell, Dale R.;Offermann, Daniel A.;Palmer, James T.;Palmer, Nicholas;Pitt, Gary R.W.;Pommier, Stéphanie;Price, Daniel;Narasinga Rao;Saxena, Rashmi;Shukla, Tarun;Singh, Amit K.;Singh, Mahipal;Srivastava, Anil;Steele, Christopher;Stokes, Neil R.;Thomaides-Brears, Helena B.;Tyndall, Edward M.;Watson, David;Haydon, David J. [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 24,p. 6598 - 6603]