ChemicalBook CAS DataBase List Octadecanedioic acid, 1-methyl ester

Octadecanedioic acid, 1-methyl ester synthesis

8synthesis methods

Product Name:Octadecanedioic acid, 1-methyl ester
CAS Number:72849-35-5
Molecular formula:C19H36O4
Molecular Weight:328.49

1472-93-1 Synthesis

1472-93-1
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$22.00/1g

72849-35-5
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$24.00/100mg

Yield: 86.8%

Reaction Conditions:

with methanol;barium(II) hydroxide at 20; for 48 h;

Steps:

1 Step 1: Synthesis of Intermediate 01-103-2
To a stirred solution of 01-103-1 (3 g, 8.76 mmol) in MeOH (15 mL) at RT was added slowly Ba(OH)2 (0.75 g, 4.4 mmol). The resulting mixture was stirred at RT. After 48 h, the reaction mixture was quenched with ice water, acidified with 1.5 M HCl, and extracted with EtOAc. The combined organic extract was washed with water, brine, dried over Na2SO4, and then evaporated to yield crude 01-103-2. Purification by column chromatography (10% EtOAc in petroleum ether) afforded 01-103-2 as an off-white solid (2.5 g, 86.8%).

References:

DTX PHARMA, INC. WO2021/108662, 2021, A1 Location in patent:Paragraph 0852