![](/CAS/GIF/843666-40-0.gif)
18-(tert-Butoxy)-18-oxooctadecanoic Acid synthesis
- Product Name:18-(tert-Butoxy)-18-oxooctadecanoic Acid
- CAS Number:843666-40-0
- Molecular formula:C22H42O4
- Molecular Weight:370.57
![OCTADECANEDIOIC ACID](/CAS/GIF/871-70-5.gif)
871-70-5
338 suppliers
$10.00/1g
![1,1-Di-tert-butoxytrimethylamine](/CAS/GIF/36805-97-7.gif)
36805-97-7
149 suppliers
$29.00/1g
![18-(tert-Butoxy)-18-oxooctadecanoic Acid](/CAS/GIF/843666-40-0.gif)
843666-40-0
304 suppliers
$7.00/100mg
Yield:843666-40-0 86%
Reaction Conditions:
in toluene at 95;Inert atmosphere;
Steps:
1.B B. 18-(tertbutoxy)-18-oxooctadecanoic acid
A suspension of octadecanedioic acid (40 g, 127 mmol) in toluene (500 ml) was heated at 95 °C under nitrogen. To the resulting solution, was added N,N-dimethylformamide di- tert-butylacetal (98 g, 434 mmol), dropwise over 3-4 hr. The reaction was stirred overnight at the same temperature, concentrated to dryness in vacuo and placed under high vacuum overnight. The resulting solid was suspended in CH2Cl2 (200 ml) with heat and sonication, and filtered at RT, washing with CH2Cl2. The filtrate (2) was concentrated to give the product as a solid (45 g, 86 %) which was used without further purification.
References:
WO2021/168386,2021,A1 Location in patent:Paragraph 00168-00169
![OCTADECANEDIOIC ACID](/CAS/GIF/871-70-5.gif)
871-70-5
338 suppliers
$10.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
825 suppliers
$13.50/25G
![18-(tert-Butoxy)-18-oxooctadecanoic Acid](/CAS/GIF/843666-40-0.gif)
843666-40-0
304 suppliers
$7.00/100mg
![OCTADECANEDIOIC ACID](/CAS/GIF/871-70-5.gif)
871-70-5
338 suppliers
$10.00/1g
![18-(tert-Butoxy)-18-oxooctadecanoic Acid](/CAS/GIF/843666-40-0.gif)
843666-40-0
304 suppliers
$7.00/100mg
![Tetradecanedioic acid](/CAS/GIF/821-38-5.gif)
821-38-5
275 suppliers
$6.00/100mg
![18-(tert-Butoxy)-18-oxooctadecanoic Acid](/CAS/GIF/843666-40-0.gif)
843666-40-0
304 suppliers
$7.00/100mg
![Octadecanedioyl dichloride](/CAS/20210111/GIF/45270-18-6.gif)
45270-18-6
0 suppliers
inquiry
![18-(tert-Butoxy)-18-oxooctadecanoic Acid](/CAS/GIF/843666-40-0.gif)
843666-40-0
304 suppliers
$7.00/100mg