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N,N-Dimethylformamide di-tert-butyl acetal

N,N-Dimethylformamide di-tert-butyl acetal structure

CAS No.: 36805-97-7

Chemical Name:: N,N-Dimethylformamide di-tert-butyl acetal

Synonyms: 1,1-di-tert-butoxy-N,N-dimethylmethanamine;N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL;N,N-Di-tert-butoxytrimethylamine;1,1-DI-TERT-BUTOXYTRIMETHYLAMINE;Di-tert-butoxyMethyl-diMethyl-aMine;Di-tert-butoxy(dimethylamino)methane;N,N-Dimethyldi-tert-butoxymethanamine;[bis(tert-butoxy)methyl]dimethylamine;N,N-DIMETHYLFORMAMIDE DI-T-BUTYL ACETAL;N,N-Dimethyldi(tert-butyloxy)methanamine

CBNumber:: CB5296219

Molecular Formula:: C11H25NO2

Molecular Weight:: 203.32

MDL Number:: MFCD00015002

MOL File:: 36805-97-7.mol

MSDS File:: SDS

Last updated:2024-08-14 09:25:04

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N,N-Dimethylformamide di-tert-butyl acetal Properties

Boiling point	56-57 °C8 mm Hg(lit.)
Density	0.848 g/mL at 25 °C(lit.)
refractive index	n20/D 1.413(lit.)
Flash point	93 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Miscible with toluene and benzene.
pka	5.34±0.50(Predicted)
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	0.848
Sensitive	Moisture Sensitive
BRN	969629
InChI	InChI=1S/C11H25NO2/c1-10(2,3)13-9(12(7)8)14-11(4,5)6/h9H,1-8H3
InChIKey	DBNQIOANXZVWIP-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(OC(C)(C)C)N(C)C
CAS DataBase Reference	36805-97-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

10-36/37/38

Safety Statements

26-36

RIDADR

UN 1993 3/PG 3

WGK Germany

10-21

HazardClass

PackingGroup

III

HS Code

29221990

NFPA 704

	2
2		0

N,N-Dimethylformamide di-tert-butyl acetal price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	40263	N,N-Dimethylformamide di-tert-butyl acetal technical, ≥90% (GC)	36805-97-7	10ml	$406	2024-03-01	Buy
Sigma-Aldrich	40263	N,N-Dimethylformamide di-tert-butyl acetal technical, ≥90% (GC)	36805-97-7	50mL	$876	2024-03-01	Buy
Sigma-Aldrich	395005	N,N-Dimethylformamide di-tert-butyl acetal for GC derivatization	36805-97-7	5ml	$91.7	2022-05-15	Buy
Sigma-Aldrich	395005	N,N-Dimethylformamide di-tert-butyl acetal for GC derivatization	36805-97-7	10x1ml	$207	2022-05-15	Buy
TCI Chemical	D1303	N,N-Dimethylformamide Di-tert-butyl Acetal [for Esterification] >98.0%(N)	36805-97-7	5mL	$115	2024-03-01	Buy

Product number	Packaging	Price	Buy
40263	10ml	$406	Buy
40263	50mL	$876	Buy
395005	5ml	$91.7	Buy
395005	10x1ml	$207	Buy
D1303	5mL	$115	Buy

N,N-Dimethylformamide di-tert-butyl acetal Chemical Properties,Uses,Production

Uses

N,N-Dimethylformamide di-tert-butyl acetal may be used in the synthesis of following:

(S)-2-(1-tert-butoxycarbonyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}ethylamino)benzoic acid methyl ester
3-O-tert-butylmorphine
tert-butylesters of pyrrole- and indolecarboxylic acids

Uses

Reagent used for the preparation of indolizines via intermolecular cyclization of picolinium salts.

Synthesis Reference(s)

Synthetic Communications, 15, p. 723, 1985 DOI: 10.1080/00397918508063864

General Description

N,N-Dimethylformamide di-tert-butyl acetal is an derivatizing reagent.

Synthesis

A mixture of 59.5 g (0.5 mol) of N, N-dimethylformamide dimethyl acetal and 147 mL (1.5 mol) of dry tert-butanol in a three-necked flask (250 mL) fitted with a thermometer magnetic stirrer, nitrogen inlet and a 33 x 1.9 cm silvered vacuum jacketed Goodloe column which was equipped with a reflux controlled take-off distilling head was heated at reflux for 1 hr, then 300 mg of 2,4,6-tri-tert-butylphenol was added. The reaction mixture was heated at 100-115°C for 48 hrs, during which time, at the rate of two drops/min, 56 mL of distillate was collected. Another 50 mL (0.52 mol) of tert-butanol was added to the reaction mixture, and the removal of methanol was continued for an additional 42 hrs to afford 64 mL of distillate. Distillation of the crude product with a similar but smaller column (20 x 1.4 cm) gave 53.2 g (52%) of N, N-Dimethylformamide di-tert-butyl acetal[1].

References

[1] Mohacsi, E. “A New Synthetic Method for the Preparation of N,N-Dimethylformamide DI-Tert-Butyl Acetal.” Synthetic Communications 15 1 (1985): 723–725.

N,N-Dimethylformamide di-tert-butyl acetal synthesis

Synthesis of N,N-Dimethylformamide di-tert-butyl acetal from Potassium tert-butoxide and [(dimethylamino)methylene]dimethylammonium methyl sulphate

N,N-Dimethylformamide di-tert-butyl acetal Preparation Products And Raw materials

Raw materials

Preparation Products

t-butyl 6-bromo-3-pyridinecarboxylate Ne-Boc-L-lysine tert-butyl ester hydrochloride 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-diMethylethyl ester tert-butyl 3-bromo-4-methylbenzoate 5,6-Dichloro-nicotinic acid tert-butyl ester

18-(tert-Butoxy)-18-oxooctadecanoic Acid

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N,N-Dimethylformamide di-tert-butyl acetal Suppliers

Global( 163)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shijiazhuang Leon Chemicals Co.,Ltd	+8615203111882	leonchem@outlook.com	China	4	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29885	58
Klong Industrial Co., Ltd	0086-519-68231162	info@klongchem.com	CHINA	131	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	938	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Shijiazhuang Leon Chemicals Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Klong Industrial Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Jinan Liheng Biotechnology Co., Ltd.	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from N,N-Dimethylformamide di-tert-butyl acetal manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-09-12	N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL 36805-97-7	US $1.00-1.00 / kg	1kg	90%	10 tons	Shijiazhuang Leon Chemicals Co.,Ltd
	2019-07-07	1,1-Di-tert-butoxytrimethylamine 36805-97-7	US $1.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL
36805-97-7
US $1.00-1.00 / kg
90%
Shijiazhuang Leon Chemicals Co.,Ltd

1,1-Di-tert-butoxytrimethylamine
36805-97-7
US $1.00 / KG
99%
Career Henan Chemical Co

N,N-Dimethylformamide di-tert-butyl acetal Spectrum

1,1-Di-tert-butoxytrimethylamine(36805-97-7)¹HNMR 1,1-Di-tert-butoxytrimethylamine(36805-97-7)¹³CNMR 1,1-Di-tert-butoxytrimethylamine(36805-97-7)IR1 1,1-Di-tert-butoxytrimethylamine(36805-97-7)Raman

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1-TERT-BUTOXY-1-METHOXY-TRIMETHYLAMINE

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N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACET AL, DERIVATIZATION GRADE 1,1-Di-tert-butoxytrimethylamine, 1,1-Di-tert-butoxy-N,N-dimethylmethylamine N,N-Dimethyl-1,1-bis[(2-methylpropan-2-yl)oxy]methanamine Di-tert-butoxy(dimethylamino)methane N,N-Dimethyldi(tert-butyloxy)methanamine N,N-Dimethyldi-tert-butoxymethanamine N,N-Dimethylformamide di-tert-butyl acetal, tech. 90% N,N-Dimethylformamide Di-tert-butyl Acetal [for Esterification] N,N-Dimethylformamide di-tert-butyl acetal,1,1-Di-tert-butoxy-N,N-dimethylmethylamine, 1,1-Di-tert-butoxytrimethylamine Di-tert-butoxyMethyl-diMethyl-aMine N,N-Di-tert-butoxytrimethylamine N,N-Dimethylformamide Di-tert-butyl Acetal N,N-Dimethylformamide di-tert-butyl acetal, technical, 90% N,N-DiMethylforMaMide Di-tert-butyl Acetal [for Esterification], 98.0%(N) N,N-DIMETHYLFORMAMIDE DI-T-BUTYL ACETAL N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACET AL, TECH., 90+% 1,1-bis(1,1-dimethylethoxy)-n,n,n-trimethylamine 1,1-Di-tert-butoxy-N,N-dimethylmethylamine 1,1-DI-TERT-BUTOXYTRIMETHYLAMINE [bis(tert-butoxy)methyl]dimethylamine Di-tert-butyl dimethylformamide acetal (DMF di-tert-butyl acetal) N,N-Dimethylformamide Di-tert-butyl Acetal [for Esterification]> Methanamine, 1,1-bis(1,1-dimethylethoxy)-N,N-dimethyl- 1,1-di-tert-butoxy-N,N-dimethylmethanamine N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL 36805-97-7 CH32NCHOCH332 CH32NCHOCCH332 C11H25NO2 GC Derivatizing Reagents Esterification & Alkylation (GC Derivatizing Reagents) N,N-Dimethylformamide Dialkylacetals (GC Derivatizing Reagents) Building Blocks Analytical Standards Alphabetic Analytical Chromatography Product Catalog Organic Building Blocks DID - DIN Acetals/Ketals/Ortho Esters Oxygen Compounds Analytical Chemistry Esterification & Alkylation (GC Derivatizing Reagents) GC Derivatizing Reagents N,N-Dimethylformamide Dialkylacetals (GC Derivatizing Reagents)