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ChemicalBook CAS DataBase List Pentachloropyridine

Pentachloropyridine synthesis

7synthesis methods
Pentachloropyridine can be produced through a direct electrophilic substitution reaction between pyridine and chlorine.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: C2Cl6; nBu4NBr; aq. NaOH / 4 h / 50 °C
2: 71 percent / C2Cl6; nBu4NBr; aq. NaOH / CH2Cl2 / 55 °C

References:

Joshi, Ashutosh V.;Baidossi, Mubeen;Qafisheh, Nida;Chachashvili, Elsa;Sasson, Yoel [Tetrahedron Letters,2004,vol. 45,# 26,p. 5061 - 5063]

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