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Phenyl(4-(prop-2-yn-1-yl)piperazin-1-yl)methanone synthesis

2synthesis methods
-

Yield:72955-72-7 28%

Reaction Conditions:

Stage #1: N-Benzoylpiperazinewith potassium carbonate in N,N-dimethyl-formamide; for 0.25 h;
Stage #2: propargyl bromide in N,N-dimethyl-formamide at 60; for 8 h;

References:

Dong, Xue;Gao, Lu;He, Yuanhang;Li, Linjie;Song, Zhenlei;Wang, Qiantao;Wang, Wanshu;Zhou, Song [Journal of the American Chemical Society,2021,vol. 143,# 29,p. 11141 - 11151] Location in patent:supporting information