PHENYL-PYRIDIN-3-YL-METHANOL synthesis

13synthesis methods

Product Name:PHENYL-PYRIDIN-3-YL-METHANOL
CAS Number:6270-47-9
Molecular formula:C12H11NO
Molecular Weight:185.22

5424-19-1 Synthesis

5424-19-1
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$20.00/10g

6270-47-9
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$350.00/250mg

Yield:6270-47-9 100%

Reaction Conditions:

with sodium tetrahydridoborate in ethanol at 25; for 2 h;

Steps:

81.1 Step 1 Phenyl (pyridin-3-yl) methanol

A mixture of phenyl (pyridin-3-yl) methanone (2.0 g, 11 mmol) and sodium borohydride (623 mg, 16 mmol) in EtOH (30 mL) was stirred at 25 for 2 h. The mixture was then concentrated, diluted with water (20 mL) and extracted with EtOAc (20 mL × 3) . The combined organic layers were washed with brine (20 mL) , dried over anhydrous sodium sulfate, filtered and concentrated to give the desired product (2.0 g, 100) as yellow oil. LCMS (ESI) : m/z 184.3 [M+H]⁺.

References:

WO2015/78374,2015,A1 Location in patent:Page/Page column 206

500-22-1 Synthesis