Pivalic-d6 Acid synthesis
1synthesis methods
- Product Name:Pivalic-d6 Acid
- CAS Number:95926-89-9
- Molecular formula:C5H10O2
- Molecular Weight:102.13
Yield:95926-89-9 59%
Reaction Conditions:
Stage #1: 2-<(2)H3>methylpropanoic acidwith lithium diisopropyl amide in tetrahydrofuran at 0 - 80; for 2 h;Inert atmosphere;
Stage #2: iodomethane-d3 in tetrahydrofuran at 0 - 80; for 10 h;Inert atmosphere;
References:
WO2019/233447,2019,A1 Location in patent:Page/Page column 96-97