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ChemicalBook CAS DataBase List Plerixafor Impurity 7

Plerixafor Impurity 7 synthesis

2synthesis methods
-

Yield:117152-72-4 81.39%

Reaction Conditions:

with triethylamine in dichloromethane at 30; for 10 h;Cooling with ice;Reagent/catalyst;

Steps:

2.1

(1) 30.0 g of 1,4,8,11-tetraazacyclotetradecane was dissolved in 1 L of dry methylene chloride, and 52 mL of triethylamine and 48.5 g of p-toluenesulfonyl chloride were added under an ice bath to obtain a colorless solution. The solution was reacted at 30°C for 10 hours.The reaction was directly spin-dried and purified by column chromatography to give Compound IV as a white foamy solid 62g, yield 81.39%;

References:

CN107586280,2018,A Location in patent:Paragraph 0031; 0039

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