![](/CAS/GIF/104632-25-9.gif)
Pramipexole Impurity 4 synthesis
- Product Name:Pramipexole Impurity 4
- CAS Number:104632-25-9
- Molecular formula:C10H19Cl2N3S
- Molecular Weight:284.25
![Pramipexole](/CAS/GIF/104632-26-0.gif)
104632-26-0
303 suppliers
$8.00/50mg
![Pramipexole Impurity 4](/CAS/GIF/104632-25-9.gif)
104632-25-9
294 suppliers
$6.00/10mg
Yield:104632-25-9 98%
Reaction Conditions:
with hydrogenchloride in water;acetone at 0 - 3; pH=1.5; for 2 h;Product distribution / selectivity;
Steps:
8
Example 8 (S)-2-Amino-6-(n-propyl)amino-4,5,6,7-tetrahydrobenzothiazole dihydrochloride monohydrate, (S)-pramipexole dihydrochloride monohydrate (I·2 HCl·1 H2O) A solution of (S)-pramipexole free base (Ia) (24.30 g) in acetone (730 ml) was cooled to 0-3°C, its pH was adjusted to 1.5 by the addition of 37% hydrochloric acid. The mixture was stirred at that temperature for 2 h and the precipitated crystals were collected by filtration. The cake was washed with cold acetone and air-dried to give 34.16 g (98%) product with m.p. 278-280°C. HPLC (purity, A%): 99.95%, [α]D20: -67.3 (c = 1.0, MeOH), optical purity (A%) (HPLC, using a chiral, optically active stationary phase): 99.6% ee.
References:
EP1878731,2008,A1 Location in patent:Page/Page column 11
![Pramipexole EP Impurity E](/CAS/GIF/106006-84-2.gif)
106006-84-2
161 suppliers
$65.00/10mg
![Pramipexole Impurity 4](/CAS/GIF/104632-25-9.gif)
104632-25-9
294 suppliers
$6.00/10mg
![2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6S)-, 4-methylbenzenesulfonate (1:1)](/CAS/20211123/GIF/943319-02-6.gif)
943319-02-6
0 suppliers
inquiry
![Pramipexole Impurity 4](/CAS/GIF/104632-25-9.gif)
104632-25-9
294 suppliers
$6.00/10mg
![tert-butyl (S)-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)carbamate](/CAS/20210305/GIF/1265141-51-2.gif)
1265141-51-2
2 suppliers
inquiry
![Pramipexole Impurity 4](/CAS/GIF/104632-25-9.gif)
104632-25-9
294 suppliers
$6.00/10mg
![Pramipexole Impurity 4](/CAS/GIF/104632-25-9.gif)
104632-25-9
294 suppliers
$6.00/10mg