prednisolone 17-ethylcarbonate synthesis
- Product Name:prednisolone 17-ethylcarbonate
- CAS Number:104286-02-4
- Molecular formula:C24H32O7
- Molecular Weight:432.51
![Pregna-1,4-diene-3,20-dione, 17,21-[(diethoxymethylene)bis(oxy)]-11-hydroxy-, (11β)-](/CAS/20210305/GIF/26129-79-3.gif)
26129-79-3
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104286-02-4
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$145.00/50mg
Yield:104286-02-4 99.3%
Reaction Conditions:
with acetic acid in ethanol;water at 40;Temperature;Reagent/catalyst;Solvent;
Steps:
1-8 Example 4:
The compound of formula II (58.5 g) was dissolved in ethanol (585 mL), water (230 mL) was added, glacial acetic acid (34.5 g) was added at 40 ° C, and the reaction was stirred for 2-3 hours. The reaction was detected to be complete by TLC. The reaction solution was concentrated under reduced pressure to remove ethanol, extracted twice with ethyl acetate, and washed once with saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain 54.0 g of a compound of formula III in a yield of 99.3% and a purity of 76.7%.
References:
CN110684068,2020,A Location in patent:Paragraph 0025-0041
73771-04-7
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5740-62-5
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104286-02-4
21 suppliers
$145.00/50mg