Pregabalin Impurity 7 synthesis

Yield:-

Reaction Conditions:

in water at 40 - 45; for 0.5 h;

Steps:

5

Example 5: Preparation of 3-(aminomethyl)N,N-diethyl-5-methyI hexanamide D(-) tartarate salt.; 3 -methyl amino N,N-diethyl-5 -methyl hexanamide (10 grams) was suspended in water and added D (-) tartaric acid (7 grams). The reaction mixture was slowly heated to 40-45°C and stirred for 30 min and filtered to remove the un-dissolved material. The filtrate was cooled to 20°C and stirred at 15-20° C for 1 hour. Filtered the solid obtained, washed with water and dried the material at 40-45°C to obtain the title compound.Yield: 6.1 grams.Specific optical Rotation: [α]_D²⁵ = -9.2° (c=l, water)

References:

WO2009/1372,2008,A2 Location in patent:Page/Page column 27