Propanamide, N-4-piperidinyl- synthesis

6synthesis methods

Product Name:Propanamide, N-4-piperidinyl-
CAS Number:139112-22-4
Molecular formula:C8H16N2O
Molecular Weight:156.23

Propanamide, N-[1-(phenylmethyl)-4-piperidinyl]-

139062-93-4
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139112-22-4
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Yield:139112-22-4 99%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;palladium(II) hydroxide in ethanol; under 2585.81 Torr; for 24.75 h;Inert atmosphere;

Steps:

Synthesis of N-(piperidin-4-yl)propionamide

0.7 g of N-(1-benzylpiperidin-4-yl)propionamide (1 equivalent, 0.003 moles) were added to a parr hydrogenation flask and dissolved in 30 mL of EtOH. The solution was then degassed with argon for 30 min followed by the addition of 0.07 g of 10% Pd/C (0.2 equiv., 6.58 x 10^"4 mol) and 0.07 g of 20% Pd(OH)₂ (0.17 equiv., 4.98 x 10^-4 mol). The black solution was then degassed with argon for an additional 1 5 min. The reaction mixture was then charged with 50 psi of H₂ gas and shaken for 24 h. The product was filtered through celite and the solvent was removed via rotary evaporation. No further purification was required. Yield: 0.467 g (99%)

References:

WO2016/29218,2016,A1 Location in patent:Page/Page column 14