PROPIONIC-2,2-D2 ACID synthesis
- Product Name:PROPIONIC-2,2-D2 ACID
- CAS Number:14770-51-5
- Molecular formula:C3H3D3O2
- Molecular Weight:77.1
19136-91-5
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$350.00/1.5mg
14770-51-5
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$104.00/1g
Yield:14770-51-5 77%
Reaction Conditions:
with deuteromethanol at 69;
Steps:
1
Synthesis of 2,2-d2-Propanoic-OD acid (21).; A solution of 2,2-d2-propanoic acid 20 (CDN, 98.5 atom% D, 15.00 g, 197 mmol) in methanol-di (Aldrich, 99.5 atom % D, 40 mL) was slowly distilled at atmospheric pressure until the distillate temperature exceeded 69 0C. Methanol-d] (40 mL) was added to the acid and distilled off three times to give 2,2-d2-propanoic-OD acid 21 (11.68 g, 77%). The complete hydrogen-to-deuterium exchange was verified by 1H NMR in the presence of triphenylmethane as standard.
References:
WO2009/51747,2009,A1 Location in patent:Page/Page column 23-24
516-05-2
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14770-51-5
15 suppliers
$104.00/1g
609-08-5
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$5.00/10g
14770-51-5
15 suppliers
$104.00/1g