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Pyridine, 2-methyl-5-(phenylmethoxy)- synthesis

3synthesis methods
-

Yield:63793-98-6 97%

Reaction Conditions:

Stage #1: 5-Hydroxy-2-methylpyridinewith tetrabutylammomium bromide;potassium hydroxide in tetrahydrofuran at 20; for 0.166667 h;
Stage #2: benzyl bromide in tetrahydrofuran at 20; for 48 h;

References:

Wang, Junfeng;Wang, Huan;Ramsay, Ian A.;Erstad, Derek J.;Fuchs, Bryan C.;Tanabe, Kenneth K.;Caravan, Peter;Gale, Eric M. [Journal of Medicinal Chemistry,2018,vol. 61,# 19,p. 8811 - 8824]