PYRUVIC ALDEHYDE 1-PHENYLHYDRAZONE synthesis

6synthesis methods

Product Name:PYRUVIC ALDEHYDE 1-PHENYLHYDRAZONE
CAS Number:5391-74-2
Molecular formula:C9H10N2O
Molecular Weight:162.19

100-63-0 Synthesis

100-63-0
359 suppliers
$10.00/1g

78-98-8
290 suppliers
$10.60/1gm:

5391-74-2
13 suppliers
$30.00/20mg

Yield:5391-74-2 100%

Reaction Conditions:

with acetic acid in water at 20;

Steps:

1

Pyrazolospiroketone Preparation 1; 2'-Phenyl-2'H-spirorpiperidine-4₁5'-pyranor3.2-clpyrazon-7'(6'H)-one ; To a solution of phenylhydrazine (10.0 g, 92.5 mmol) in water (30 ml_) was added acetic acid (8.8 ml_) followed by the dropwise addition of pyruvaldehyde (16.7 g, 92.5 mmol) in water (400 ml_) over a 15 minute period. The solution was stirred at room temperature overnight. The reaction was filtered and the resultant solid was washed with water (2 x 30 ml_) to provide 2-oxopropanal phenylhydrazone as a yellow solid (15.2 g, 101%).

References:

WO2009/144554,2009,A1 Location in patent:Page/Page column 15-16