ChemicalBook CAS DataBase List (R)-1-(4-METHOXYBENZYL)-1 2 3 4 5 6 7 8&

(R)-1-(4-METHOXYBENZYL)-1 2 3 4 5 6 7 8& synthesis

9synthesis methods

Product Name:(R)-1-(4-METHOXYBENZYL)-1 2 3 4 5 6 7 8&
CAS Number:30356-08-2
Molecular formula:C17H23NO
Molecular Weight:257.37

1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

51072-36-7
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(R)-1-(4-METHOXYBENZYL)-1 2 3 4 5 6 7 8&

30356-08-2
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Yield: 494.5 g

Reaction Conditions:

with (R)-Mandelic Acid in acetone at 25 - 45;Large scale;Reagent/catalyst;

Steps:

4 Example 4
1 kg of the intermediate of formula (I) and 2.8 L of acetone were added to the flask. Stirring at 25 ~ 30°C for 25 to 30 minutes. Then heated to 40 ~ 45°C. Slowly added D-mandelic acid 0.35 kg for chemical resolution. The filtrate was collected after the split; Take one of the filtrate, washed once with 2 L of 10 mol / L sodium hydroxide, 2L water washed twice. The organic phases were combined. Dried over anhydrous sodium sulfate. Filtered and concentrated under reduced pressure to give 1,2,3,4,5,6,7,8-octahydro-R-1-[(4-methoxyphenyl)methyl]isoquinoline formula (III) 494.5 g, HPLC purity 99.7%, the recovery was 98.9%.

References:

Zhejiang Yongtai Pharmaceutical Co., Ltd.;Huang, Jinfeng;Zhou, Guobin;He, Renbao;Zhang, Leigang CN106083717, 2016, A Location in patent:Paragraph 0039; 0040

51072-35-6 Synthesis