(R)-(+)-1-Boc-3-aminopyrrolidine synthesis
- Product Name:(R)-(+)-1-Boc-3-aminopyrrolidine
- CAS Number:147081-49-0
- Molecular formula:C9H18N2O2
- Molecular Weight:186.25
143700-04-3
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147081-49-0
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Yield:147081-49-0 96%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; for 12 h;
Steps:
72.1
A mixture of (R) -tert-butyl 3-azidopyrrolidine-1-carboxylate (250 mg, 1.18 mmol) and Pd/C (10, 50 mg) in methanol (10 mL) was stirred at rt under H2 at atmospheric pressure for 12 h and filtered. The filtrate was concentrated to give (R) -tert-butyl 3-aminopyrrolidine-1-carboxylate as colorless liquid (210 mg, 96) .1H NMR (600 MHz, CDCl3) : δ ppm 3.39-3.49 (m, 3H) , 3.27-3.32 (m, 1H) , 2.95-3.03 (m, 1H) , 1.98-2.08 (m, 1H) , 1.63-1.70 (m, 1H) , 1.41 (s, 9H) and MS-ESI: m/z 131.20 [M-55] +.
References:
SUNSHINE LAKE PHARMA CO., LTD.;ZHANG, Yingjun;LIU, Bing;YU, Tianzhu;ZHANG, Xiangyu;ZHANG, Shiguo;ZHANG, Jiancun;CHENG, Changchung WO2016/34134, 2016, A1 Location in patent:Paragraph 00508
132945-75-6
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147081-49-0
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24424-99-5
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116183-82-5
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147081-49-0
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1013-88-3
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24424-99-5
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116183-82-5
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4248-19-5
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147081-49-0
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186550-13-0
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101385-93-7
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147081-49-0
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