![](/CAS/GIF/109431-87-0.gif)
(R)-1-Boc-3-hydroxypyrrolidine synthesis
- Product Name:(R)-1-Boc-3-hydroxypyrrolidine
- CAS Number:109431-87-0
- Molecular formula:C9H17NO3
- Molecular Weight:187.24
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
820 suppliers
$13.50/25G
![(R)-(-)-3-Pyrrolidinol hydrochloride](/CAS/GIF/104706-47-0.gif)
104706-47-0
373 suppliers
$8.00/5g
![(R)-1-Boc-3-hydroxypyrrolidine](/CAS/GIF/109431-87-0.gif)
109431-87-0
352 suppliers
$5.00/1g
Yield:109431-87-0 99%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 0.12 h;
Steps:
1 Synthesis of tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate:
To a stirred solution of (R)-pyrrolidin-3-ol hydro chloride (3.0 g, 24.2 mmol) in DCM (30 ml), were added N(Et)3(10.2 ml, 72.8 mmol) and (Boc)20 (6 ml, 26.7 mmol) at 0 °C. The reaction mixture was allowed to stir at room temperature for about 12 hours. After 12 hours of stirring, saturated NH4C1 was added. The solution was extracted with EtOAc (2x60 mL). The combined organic phases were washed with brine, dried over Na2S04and concentrated under reduced pressure to give the crude product. Purification by flash chromatography with EtOAc-hexane (4: 6) as an eluent to afford the desired product (4.5 g, yield: 99%) as an oil.
References:
WO2017/17630,2017,A1 Location in patent:Page/Page column 36
![N-Boc-3-pyrrolidinone](/CAS/GIF/101385-93-7.gif)
101385-93-7
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![(R)-1-Boc-3-hydroxypyrrolidine](/CAS/GIF/109431-87-0.gif)
109431-87-0
352 suppliers
$5.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
820 suppliers
$13.50/25G
![L-Hydroxyproline](/CAS/GIF/51-35-4.gif)
51-35-4
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![(R)-1-Boc-3-hydroxypyrrolidine](/CAS/GIF/109431-87-0.gif)
109431-87-0
352 suppliers
$5.00/1g
![N-Boc-3-pyrrolidinone](/CAS/GIF/101385-93-7.gif)
101385-93-7
473 suppliers
$5.00/1g
![(R)-1-Boc-3-hydroxypyrrolidine](/CAS/GIF/109431-87-0.gif)
109431-87-0
352 suppliers
$5.00/1g
![N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol](/CAS/GIF/101469-92-5.gif)
101469-92-5
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![(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid](/CAS/GIF/135042-12-5.gif)
135042-12-5
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![(R)-1-Boc-3-hydroxypyrrolidine](/CAS/GIF/109431-87-0.gif)
109431-87-0
352 suppliers
$5.00/1g