![](/CAS/GIF/10009-70-8.gif)
(R)-(+)-2-BROMOPROPIONIC ACID synthesis
- Product Name:(R)-(+)-2-BROMOPROPIONIC ACID
- CAS Number:10009-70-8
- Molecular formula:C3H5BrO2
- Molecular Weight:152.97
![(S)-2-((Methylsulfonyl)oxy)propanoic acid](/CAS/20150408/GIF/66423-08-3.gif)
66423-08-3
20 suppliers
inquiry
![(R)-(+)-2-BROMOPROPIONIC ACID](/CAS/GIF/10009-70-8.gif)
10009-70-8
107 suppliers
$65.00/1 g
Yield: 45%
Reaction Conditions:
Stage #1:(S)-2-(methylsulfonyloxy)propionic acid with lithium bromide in toluene at 60; for 1 h;
Stage #2: in water;toluene at 20; for 0.5 h;
Steps:
28 (Example 28) (R)-2-Bromopropionic acid
(Example 28) (R)-2-Bromopropionic acid lithium bromide (0.26 g) was added to a mixture prepared by adding 10 ml of toluene to 0.50 g of (S)-2-methanesulfonyloxypropionic acid (obtained in Example 16), the resulting mixture was stirred at 60°C for 1 hour and then cooled to 20°C, 5 ml of pure water was added and, after 30 minutes of stirring at 20°C, the organic layer was separated.. The thus-obtained organic layer contained 0.19 g of (R) -2-bromopropionic acid (yield 45%, optical purity 92.3% ee).. The rate of configuration inversion from methyl L-lactate was 92.3%.
References:
KANEKA CORPORATION EP1422215, 2004, A1 Location in patent:Page 23
![D-Alanine](/CAS/GIF/338-69-2.gif)
338-69-2
588 suppliers
$5.00/10g
![(R)-(+)-2-BROMOPROPIONIC ACID](/CAS/GIF/10009-70-8.gif)
10009-70-8
107 suppliers
$65.00/1 g
![L-Alanine](/CAS/GIF/56-41-7.gif)
56-41-7
775 suppliers
$5.00/5g
![(R)-(+)-2-BROMOPROPIONIC ACID](/CAS/GIF/10009-70-8.gif)
10009-70-8
107 suppliers
$65.00/1 g
![2-Bromopropionic acid](/CAS/GIF/598-72-1.gif)
598-72-1
340 suppliers
$15.00/25g
![(S)-(-)-2-BROMOPROPIONIC ACID](/CAS/GIF/32644-15-8.gif)
32644-15-8
132 suppliers
$79.00/5g
![(R)-(+)-2-BROMOPROPIONIC ACID](/CAS/GIF/10009-70-8.gif)
10009-70-8
107 suppliers
$65.00/1 g
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
![(S)-(-)-2-BROMOPROPIONIC ACID](/CAS/GIF/32644-15-8.gif)
32644-15-8
132 suppliers
$79.00/5g
![(R)-(+)-2-BROMOPROPIONIC ACID](/CAS/GIF/10009-70-8.gif)
10009-70-8
107 suppliers
$65.00/1 g