ChemicalBook CAS DataBase List (R)-2-Phenylpyrrolidine

(R)-2-Phenylpyrrolidine synthesis

5synthesis methods

Product Name:(R)-2-Phenylpyrrolidine
CAS Number:56523-47-8
Molecular formula:C10H13N
Molecular Weight:147.22

313352-62-4 Synthesis

313352-62-4
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56523-47-8
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Yield:56523-47-8 81%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at -5 - 20; for 2 h;

Steps:

2.4

(4) (R)-5-phenylpyrrolidin-2-one (40 g, 0.25 mol) was dissolved in tetrahydrofuran (800 mL), cooling to -5-5 deg. C, lithium aluminum hydride (23.6 g, 0.62 mol) was added in portions to keep the internal temperature below 10 ° C, and the mixture was stirred at room temperature for 2 h. Quenched with water (23.6 g), keeping the temperature within -5-5 deg. C, followed by stirring at room temperature for 1 h, filtered, and concentrated to give 30 g of a colorless oil, in 81% yield.

References:

CN104592163,2016,B Location in patent:Paragraph 0056; 0057

700-91-4 Synthesis