ChemicalBook CAS DataBase List (R)-3-Amino-3-phenylpropan-1-ol

(R)-3-Amino-3-phenylpropan-1-ol synthesis

12synthesis methods

Product Name:(R)-3-Amino-3-phenylpropan-1-ol
CAS Number:170564-98-4
Molecular formula:C9H13NO
Molecular Weight:151.21

100-52-7 Synthesis

100-52-7
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170564-98-4
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$10.00/100mg

Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: ammonium acetate / ethanol / 12 h / Reflux
2.1: sodium hydroxide / water / 8 h / 40 °C / pH 11
3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / Cooling with ice
3.2: 20 °C
4.1: Carica papaya lipase / hexane / 10 h / 45 °C / Resolution of racemate; Enzymatic reaction
5.1: hydrogenchloride / water / 10 h / Reflux
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 65 °C

References:

You, Pengyong;Qiu, Jian;Su, Erzheng;Wei, Dongzhi [European Journal of Organic Chemistry,2013,# 3,p. 557 - 565]