R)-3-PHENYL PIPERIDINE synthesis
- Product Name:R)-3-PHENYL PIPERIDINE
- CAS Number:430461-56-6
- Molecular formula:C11H15N
- Molecular Weight:161.24
3973-62-4
112 suppliers
$18.00/100mg
430461-56-6
90 suppliers
$125.00/100mg
Yield: 23.5%
Reaction Conditions:
with Di-p-toluoyl-L-tartaric acid in ethyl acetate for 2 h;Reagent/catalyst;Solvent;
Steps:
21 Preparation of (R)-3-phenylpiperidine ((R)-1)
3-Phenylpiperidine (1,100 g, 621.1 mmol) was dissolved in isopropanol (50 mL).Will be dissolved in D-tartaric acid (93.16g, 622.2mmol)Isopropyl alcohol (200mL)The solution was added dropwise to a solution of racemic 3-phenylpiperidine in isopropanol and stirred for 2 h.Filtration to obtain the tartrate salt; then, methanol (10 L) is added to the tartrate salt.After heating to complete dissolution, stop stirring; slowly cool to room temperature,The crystallization was carried out at -20 ° C for 7 days, and filtered to give a white crystals crystals crystals. 29.7 g of a white waxy solid, (R)-3-phenylpiperidine, yield 29.7%.
References:
Shanghai Bobang Pharmaceutical Technology Co., Ltd.;Liu Zhende;Cui Xiaoyuan;Gao Heyong CN108203404, 2018, A Location in patent:Paragraph 0147-0162
1000210-73-0
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430461-56-6
90 suppliers
$125.00/100mg
3973-62-4
112 suppliers
$18.00/100mg
59349-71-2
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$168.00/250mg
430461-56-6
90 suppliers
$125.00/100mg
56613-80-0
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343947-52-4
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430461-56-6
90 suppliers
$125.00/100mg
332-15-0
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430461-56-6
90 suppliers
$125.00/100mg