ChemicalBook CAS DataBase List Pergolide

Pergolide synthesis

6synthesis methods

Product Name:Pergolide
CAS Number:66104-22-1
Molecular formula:C19H26N2S
Molecular Weight:314.49

5878-43-3 Synthesis

5878-43-3
49 suppliers
inquiry

66104-22-1
69 suppliers
$40.00/10 mg

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 80 °C / Large scale
1.2: 65 °C / Large scale
1.3: 12 h / 75 °C / Large scale
2.1: pyridine / dichloromethane / 1 h / -5 °C / Inert atmosphere; Reflux; Large scale
2.2: 1 h / -5 °C / Inert atmosphere; Large scale
3.1: 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C / Inert atmosphere; Reflux; Large scale
3.2: 0 °C / Inert atmosphere; Large scale

References:

Cabri, Walter;Roletto, Jacopo;Olmo, Sara;Fonte, Piera;Ghetti, Paolo;Songia, Simonetta;Mapelli, Elio;Alpegiani, Marco;Paissoni, Paolo [Organic Process Research and Development,2006,vol. 10,# 2,p. 198 - 202]