(R)-N-BOC-2-PHENYLPYRROLIDINE synthesis

8synthesis methods

Product Name:(R)-N-BOC-2-PHENYLPYRROLIDINE
CAS Number:174311-02-5
Molecular formula:C15H21NO2
Molecular Weight:247.33

24424-99-5 Synthesis

24424-99-5
823 suppliers
$13.50/25G

(4-OXO-4-PHENYL-BUTYL)-CARBAMIC ACID TERT-BUTYL ESTER

116437-41-3
64 suppliers
$13.00/100mg

174311-02-5
19 suppliers
inquiry

Yield:174311-02-5 94%

Reaction Conditions:

Stage #1: tert-butyl (4-oxo-4-phenyl-butyl)-carbamatewith formic acid at 20; for 12 h;
Stage #2: with sodium hydrogencarbonate for 6 h;
Stage #3: di-tert-butyl dicarbonatewith Ru(Η6-cymene)(MsDPEN)(BArF);hydrogen in dichloromethane at 40; under 38002.6 Torr; for 10 h;Inert atmosphere;Autoclave;optical yield given as %ee;

References:

Chen, Fei;Ding, Ziyuan;Qin, Jie;Wang, Tianli;He, Yanmei;Fan, Qing-Hua [Organic Letters,2011,vol. 13,# 16,p. 4348 - 4351] Location in patent:supporting information; experimental part

108-86-1 Synthesis