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ChemicalBook CAS DataBase List (R,S)-N-Ethylnornicotine

(R,S)-N-Ethylnornicotine synthesis

6synthesis methods
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Yield:86900-39-2 84%

Reaction Conditions:

Stage #1: ethylamine;4-Oxo-1-(3-pyridyl)-1-butanonewith sodium tris(acetoxy)borohydride;acetic acid in tetrahydrofuran;dichloromethane at -78 - 20;
Stage #2: with Amberlyst 15 in tetrahydrofuran;dichloromethane at 20; for 1 h;
Stage #3: with triethylamine in dichloromethane at 20; for 1 h;

References:

Baxendale, Ian R.;Brusotti, Gloria;Matsuoka, Masato;Ley, Steven V. [Journal of the Chemical Society. Perkin Transactions 1 (2001),2002,vol. 2,# 2,p. 143 - 154]