Raltegravir Intermediate 2 synthesis
- Product Name:Raltegravir Intermediate 2
- CAS Number:1172131-64-4
- Molecular formula:C21H27FN4O4
- Molecular Weight:418.46
1172131-65-5
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1172131-64-4
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Yield:1172131-64-4 42.9 g
Reaction Conditions:
Stage #1: C29H33FN4O6with glycolic Acid;5%-palladium/activated carbon;hydrogen in methanol;ethyl acetate at 20; under 258.581 Torr;
Stage #2: with triethylamine in methanol;ethyl acetate at 20; pH=9;
References:
Humphrey, Guy R.;Pye, Philip J.;Zhong, Yong-Li;Angelaud, Remy;Belyk, Kevin M.;Maligres, Peter E.;Miller, Ross A.;Reamer, Robert A.;Askin, David;Mancheno, Danny E.;Weissman, Steven A. [Organic process research and development,2011,vol. 15,# 1,p. 73 - 83] Location in patent:experimental part
140-75-0
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3282-30-2
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519028-33-2
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1172131-64-4
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1172131-64-4
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