ChemicalBook CAS DataBase List Rebeprazole sodium

Rebeprazole sodium synthesis

6synthesis methods

Product Name:Rebeprazole sodium
CAS Number:117976-90-6
Molecular formula:C18H20N3NaO3S
Molecular Weight:381.42

117976-89-3 Synthesis

117976-89-3
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$15.00/1mg

117976-90-6
620 suppliers
$25.00/5mg

Yield:117976-90-6 100%

Reaction Conditions:

with sodium hydroxide in ethanolProduct distribution / selectivity;

Steps:

2; 3
Example 2 Ethanol (30 ml) was added to sodium hydroxide (2.25 g (55.1 mmol)), and dissolution was carried out. 2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole (20.0 g (55.6 mmol)) was then put into the ethanol solution, and after dissolution had been confirmed, diisopropyl ether (2000 ml) was added slowly, whereby 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole sodium salt (22.8 g) was obtained through precipitation (yield 100%).; Example 3 Ethanol (22.5 ml) was added to sodium hydroxide (1.65 g (41.3 mmol)), and dissolution was carried out. 2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole (15.0 g (41.7 mmol)) was then put into the ethanol solution, and after dissolution had been confirmed, tert-butyl methyl ether (160 ml) was added slowly, whereby 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole sodium salt (15.9 g) was obtained through precipitation (yield 100%).

References:

Urawa, Yoshio US2007/225502, 2007, A1 Location in patent:Page/Page column 5

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