RHOIFOLIN synthesis

Yield:17306-46-6 8.14 g

Reaction Conditions:

with pyridine;iodine at 95; for 2 h;Inert atmosphere;

Steps:

S1 S1 Rhoifolin Synthesis
Naringin (10.02 g, 17.25 mmol) was dissolved in 100 mL of pyridine.Under argon atmosphere, iodine (4.45 g, 17.05 mmol) was added and heated to 95 ° C for 2 h. The reaction solution was cooled to room temperature, and a pale yellow solid precipitated.The crude product was recrystallized from acetone to give the product 8.14 g.M.p. 236-238 ° C.

References:

Inner Mongolia Medical University;Zhang Zhentao;Qu Lili;Fan Liya;Ma Yuheng;Liu Hong CN108727446, 2018, A Location in patent:Paragraph 0017; 0020; 0021