(S)-1-N-Boc-3-cyanopiperidine synthesis
- Product Name:(S)-1-N-Boc-3-cyanopiperidine
- CAS Number:915226-39-0
- Molecular formula:C11H18N2O2
- Molecular Weight:210.27
88466-77-7
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915226-39-0
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$45.00/50mg
Yield: 100%
Reaction Conditions:
with pyridine;trichlorophosphate at 0 - 20;Product distribution / selectivity;
Steps:
1.B 1(B)
1(B) (S)-3-Cyano-piperidine-1-carboxylic acid tert-butyl ester Phosphorus oxychloride (812 uL, 8.72 mmol) was added dropwise at 0° C. to a solution of (S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester (2 g, 8.72 mmol) in pyridine (20 mL), under nitrogen atmosphere. After stirring overnight at room temperature, ethyl acetate was added and the solution was washed with 10% HCl (2 times). The phases were separated and the organics were dried over sodium sulphate and evaporated to dryness under reduced pressure. The title compound was used for the next step without further purification. Yield: quantitative; LCMS (RT): 4.48 min (Method A); MS (ES+) gave m/z: 211.1.
References:
NIKEM RESEARCH SRL;ADDEX PHARMA SA US2009/215822, 2009, A1 Location in patent:Page/Page column 9
88495-54-9
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$10.00/1g
915226-39-0
67 suppliers
$45.00/50mg