(S)-2,2-DIMETHYL-1,3-DIOXOLANE-4-ACETONITRILE synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 0.5 h / -20 °C / Inert atmosphere
2: water; acetonitrile / 20 °C

References:

González-Gil, Inés;Zian, Debora;Vázquez-Villa, Henar;Hernández-Torres, Gloria;Martínez, R. Fernando;Khiar-Fernández, Nora;Rivera, Richard;Kihara, Yasuyuki;Devesa, Isabel;Mathivanan, Sakthikumar;Del Valle, Cristina Rosell;Zambrana-Infantes, Emma;Puigdomenech, María;Cincilla, Giovanni;Sanchez-Martinez, Melchor;Rodríguez De Fonseca, Fernando;Ferrer-Montiel, Antonio V.;Chun, Jerold;López-Vales, Rubén;López-Rodríguez, María L.;Ortega-Gutiérrez, Silvia [Journal of Medicinal Chemistry,2020,vol. 63,# 5,p. 2372 - 2390]