(S)-2-((4-NITROPHENOXY)METHYL)OXIRANE synthesis

6synthesis methods

Product Name:(S)-2-((4-NITROPHENOXY)METHYL)OXIRANE
CAS Number:125279-82-5
Molecular formula:C9H9NO4
Molecular Weight:195.17

100-02-7 Synthesis

100-02-7
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115314-14-2
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125279-82-5
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Yield:125279-82-5 93%

Reaction Conditions:

Stage #1: 4-nitro-phenolwith cesium fluoride in N,N-dimethyl-formamide at 20; for 1 h;
Stage #2: (2s)-(+)-glycidyl 3-nitrobenzenesulfonate in N,N-dimethyl-formamide at 20; for 24 h;optical yield given as %ee;

References:

Tahirovic, Yesim A.;Geballe, Matthew;Gruszecka-Kowalik, Ewa;Myers, Scott J.;Lyuboslavsky, Polina;Le, Phuong;French, Adam;Irier, Hasan;Choi, Woo-Baeg;Easterling, Keith;Yuan, Hongjie;Wilson, Lawrence J.;Kotloski, Robert;McNamara, James O.;Dingledine, Raymond;Liotta, Dennis C.;Traynelis, Stephen F.;Snyder, James P. [Journal of Medicinal Chemistry,2008,vol. 51,# 18,p. 5506 - 5521] Location in patent:experimental part

100-02-7 Synthesis

100-02-7
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118712-60-0 Synthesis