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ChemicalBook CAS DataBase List Sertraline hydrochloride

Sertraline hydrochloride synthesis

11synthesis methods
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Yield:79559-97-0 500 mg

Reaction Conditions:

with hydrogenchloride in acetic acid methyl ester at 20; for 6 h;

Steps:

Synthesis of sertraline via asymmetric hydrogenation of imine (S)-16f:

To a stirred saturated solution of HCl in CH3COOCH3 (4 M, 10 mL), (S,S)-17f (650 mg) was added. The reaction mixture was stirred at room temperature for 6 h. The solvent were then evaporated in vacuum. The product was crystallised, filtered, and then washed twice with CH3COOCH3, giving the final product sertraline (500 mg) in 90% overall yield with >99% ee value.

References:

Chen, Fei;Ding, Ziyuan;He, Yanmei;Qin, Jie;Wang, Tianli;Fan, Qing-Hua [Tetrahedron,2012,vol. 68,# 26,p. 5248 - 5257] Location in patent:supporting information; experimental part

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