ChemicalBook CAS DataBase List SODIUM FLUOROACETATE

SODIUM FLUOROACETATE synthesis

3synthesis methods

Product Name:SODIUM FLUOROACETATE
CAS Number:62-74-8
Molecular formula:C2H2FNaO2
Molecular Weight:100.02

459-72-3 Synthesis

459-72-3
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$10.00/1g

62-74-8
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$50.00/25mg

Yield:62-74-8 99%

Reaction Conditions:

with sodium hydroxide in ethanol at 0;

Steps:

28.A Step A: Sodium 2-fluoroacetate (28-b)
Ethyl 2-fluoroacetate, 28-a, (107g, lmol) was dissolved in absolute EtOH (1L), cooled to 0°C and NaOH (40g, lmol) in EtOH was added. The reaction was stirred overnight after which petroleum ether was added. The reaction solution was cooled to -20°C and filtered giving 104g of title compound, 28-b, as white solid (yield 99 %)

References:

MERCK SHARP & DOHME CORP.;ZHOU, Changyou;ZOU, Wuxin;HUA, Yuxia;DANG, Qun WO2013/40790, 2013, A1 Location in patent:Page/Page column 87

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