ChemicalBook CAS DataBase List TAK-441

TAK-441 synthesis

7synthesis methods

Product Name:TAK-441
CAS Number:1186231-83-3
Molecular formula:C28H31F3N4O6
Molecular Weight:576.56

30414-53-0 Synthesis

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1186231-83-3
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Yield:-

Steps:

Multi-step reaction with 8 steps
1: ammonium acetate / methanol / 72 h / 10 - 35 °C
2: sodium ethanolate / ethanol / 15 h / 150 °C
3: trichlorophosphate / 0.5 h / 80 °C
4: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C
5: triethylamine / ethanol / 25 h / 80 - 100 °C
6: caesium carbonate / dimethyl sulfoxide / 5 h / 100 °C
7: sodium hydroxide; water / ethanol / 1 h / 60 °C
8: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 10 - 35 °C / Cooling

References:

Takeda Pharmaceutical Company Limited EP2471791, 2012, A1

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883528-73-2 Synthesis