Tenofovir Alafenamide synthesis

Reference: Zhang, Wei; Liao, Wensheng. Method for preparing tenofovir alafenamide Zhang, Wei; Liao, Wensheng. CN 108623632. (Shanghai Steppharm Co., Ltd., Peop. Rep. China)

Reference: Zhong, Bohua; Wang, Jianming; Jin, Xuefeng. Single isomer of phosphoric acid/phosphonic acid derivative and its medical application. CN 108129514. (Beijing Meibeita Pharmaceutical Research Co., Ltd., Peop. Rep. China)

Reference: Wang, Jianming; Chen, Xiaoguang; Chen, Junping; Fan, Shan. Phosphoric acid/phosphonic acid derivatives and medicinal uses thereof. WO 2014183462. (Beijing Meibeita Drug Res Co., Ltd, Peop. Rep. China)

Reference: Wei, Yonggang; Qiu, Guanpeng; Lu, Yonghua; Zhu, Guozhi. Method for preparing nucleoside analogue and intermediate thereof. WO 2015161781. (Sichuan Haisco Pharmaceutical Co., Ltd., Peop. Rep. China)

Chapman, H.; Kernan, M.; Prisbe, E.; Rohloff, J.; Sparacino, M.; Terhorst, T.; Yu, R. Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340. Nucleosides, Nucleotides & Nucleic Acids. Volume 20. Issue 4-7. Pages 621-628. 2001.

Becker, Mark W.; Chapman, Harlan H.; Cihlar, Tomas; Eisenberg, Eugene J.; He, Gong-Xin; Kernan, Michael R.; Lee, William A.; Prisbe, Ernest J.; Rohloff, John C.; Sparacino, Mark L. Preparation of prodrugs amino acid methoxyphosphonate acyclic nucleotide analogs as antiviral or antitumor agents and their use in therapy and prophylaxis. Assignee Gilead Sciences, Inc., USA. WO 2002008241 A2. (2002).

Vellanki, Siva Ram Prasad; Balusu, Raja Babu; Putta, Subba Rayudu; Raavi, Mastan Rao; Arikatla, Sivalakshmi Devi. Process for the preparation of tenofovir alafenamide and its pharmaceutically acceptable salts. Assignee Mylan Laboratories Ltd., India. IN 2014MU00118 A. (2015).

Thatipally, Suresh; Dammalapati, Venkata Lakshmi Narasimha Rao; Kallam, Venkata Siva Ramakrishna Reddy; Gorantla, Seeta Rama Anjaneyulu; Chava, Satyanarayana. An improved process for the preparation of tenofovir alafenamide via separation of its diastereomers by simulated moving chromatography and its pharmaceutically acceptable salts. Assignee Laurus Labs Private Limited, India. WO 2015040640 A2. (2015).