ChemicalBook CAS DataBase List TERPINYL PROPIONATE

TERPINYL PROPIONATE synthesis

4synthesis methods

Product Name:TERPINYL PROPIONATE
CAS Number:80-27-3
Molecular formula:C13H22O2
Molecular Weight:210.31

By esterification of terpineols.

98-55-5
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$19.00/25mL

123-62-6
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$16.00/25g

80-27-3
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$37.27/100G

Yield: 57.2%

Reaction Conditions:

with p-toluenesulfonyl chloride at 20; for 1.5 h;

Steps:

4.1.1 General procedure for the synthesis of compounds 2a-f
General procedure: A mixture ofα-terpineol (1, 2mmol), acid anhydride (3mL) and TsCl (0.2mmol) was stirred at room temperaturefor 1.5h, and then neutralized to pH7-8 with 10% NaOH aqueous solution, washed with water (2×10mL) and brine (10mL). The organic layer was separated and dried over anhydrous Na₂SO₄, then concentrated and purified by silica gel column chromatography (petroleum ether/ethyl acetate=1:5 v/v) to afford the desired products.

References:

Zhu, Wanping;Liu, Xia;Wang, Yuji;Tong, Yeling;Hu, Yongzhou [European Journal of Medicinal Chemistry,2018,vol. 143,p. 419 - 425]