tert-Butyl 2-(4-formylphenoxy)acetate synthesis
- Product Name:tert-Butyl 2-(4-formylphenoxy)acetate
- CAS Number:276884-77-6
- Molecular formula:C13H16O4
- Molecular Weight:236.26
5292-43-3
440 suppliers
$10.00/5g
123-08-0
900 suppliers
$5.00/10g
276884-77-6
26 suppliers
$339.50/1g
Yield:276884-77-6 97%
Reaction Conditions:
with potassium carbonate in butanone; for 2 h;Heating / reflux;
Steps:
1
Example 1 tert-Butyl [4-({[6-(4-fluoro-3-methylbenzylcarbamoyl)pyrimidine-4-carbonyl]amino}methyl)phenoxy]acetate tert-Butyl (4-formylphenoxy)acetate: 10 g (0.0819 mol) of 4-hydroxybenzaldehyde and 15.97 g (0.0819 mol) of tert-butyl bromoacetate were dissolved in 200 ml of 2-butanone, after which 11.32 g (0.0819 mol) of potassium carbonate were added and the mixture was heated under reflux for 2 hours (h). The mixture was then concentrated under reduced pressure and the residue was taken up in water and the solution was extracted three times with dichloromethane. The organic phase was dried (MgSO4), filtered and concentrated under reduced pressure. Yield: 18.72 g (97%)
References:
US2005/4111,2005,A1 Location in patent:Page/Page column 8
107-59-5
286 suppliers
$27.00/25g
123-08-0
900 suppliers
$5.00/10g
276884-77-6
26 suppliers
$339.50/1g