ChemicalBook CAS DataBase List tert-butyl 3-aminopropanoate

tert-butyl 3-aminopropanoate synthesis

5synthesis methods

Product Name:tert-butyl 3-aminopropanoate
CAS Number:15231-41-1
Molecular formula:C7H15NO2
Molecular Weight:145.2

1116-98-9 Synthesis

1116-98-9
238 suppliers
$8.00/5g

15231-41-1
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$38.00/100mg

Yield:15231-41-1 198 g

Reaction Conditions:

with ammonia;hydrogen in methanol at 55; under 37503.8 Torr; for 6 h;Sealed tube;Reagent/catalyst;Solvent;Pressure;Temperature;

Steps:

5 Example 5
The reaction vessel was charged with 200g of tert-butyl cyanoacetate was added 1kg2% methanol - ammonia solution, 20g Raney nickel was added, the reaction vessel sealed, purged with nitrogen three times, purged with hydrogen three times. Charged with hydrogen pressure 5Mpa, heated to 55 , the reaction was stirred 6h, midway continuous supply of hydrogen.After completion of the reaction, the catalyst was removed by filtration, the filtrate was concentrated to 200g of ethyl acetate was added, under cooling, was added ethyl acetate - hydrogen chloride to pH 3, the system was concentrated, the precipitated solid was dried. To give the product 198g.

References:

Zhang, Wei CN105367435, 2016, A Location in patent:Paragraph 0022; 0023

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