ChemicalBook CAS DataBase List tert-butyl 4-(phenylthio)piperidine-1-carboxylate

tert-butyl 4-(phenylthio)piperidine-1-carboxylate synthesis

5synthesis methods

Product Name:tert-butyl 4-(phenylthio)piperidine-1-carboxylate
CAS Number:154612-64-3
Molecular formula:C16H23NO2S
Molecular Weight:293.42

108-98-5
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180695-79-8 Synthesis

180695-79-8
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tert-butyl 4-(phenylthio)piperidine-1-carboxylate

154612-64-3
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Yield:154612-64-3 87%

Reaction Conditions:

Stage #1: thiophenolwith sodium hydride in N,N-dimethyl-formamide at 25; for 0.5 h;
Stage #2: tert-butyl 4-bromo-1-piperidinecarboxylate in N,N-dimethyl-formamide at 80; for 1 h;

References:

Brauns, Marcus;Cramer, Nicolai [Angewandte Chemie - International Edition,2019,vol. 58,# 26,p. 8902 - 8906][Angew. Chem.,2019,vol. 131,p. 8994 - 8998,5] Location in patent:supporting information

882-33-7 Synthesis