tetrahydrofuran-3-yl Methanesulfonate synthesis
- Product Name:tetrahydrofuran-3-yl Methanesulfonate
- CAS Number:156380-34-6
- Molecular formula:C5H10O4S
- Molecular Weight:166.2
Yield:156380-34-6 97%
Reaction Conditions:
with triethylamine in tetrahydrofuran at 0;
Steps:
21.1
To a solution of 21a (0.6g, 6.81mmol) and TEA (1.05g, 8.17mmol) in THF was added methanesulfonyl chloride (0.86g, 7.50mmol) cooled by ice-bath. The mixture was stirred over weekend and then evaporated. The residue was dissolved in EtOAc and washed with aq. NaHCO3. The organic phase was dried over Na2SO4 and 15 concentrated to provide 21b (1.Ig, 97% yield).
References:
WO2008/88881,2008,A1 Location in patent:Page/Page column 46
453-20-3
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