ChemicalBook CAS DataBase List Tetrazine-NHBoc

Tetrazine-NHBoc synthesis

8synthesis methods

Product Name:Tetrazine-NHBoc
CAS Number:1380500-93-5
Molecular formula:C14H17N5O2
Molecular Weight:287.32

66389-80-8
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3473-63-0 Synthesis

3473-63-0
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1380500-93-5
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Yield:1380500-93-5 70%

Reaction Conditions:

Stage #1: tert-butyl N-[(4-cyanophenyl)methyl]carbamate;formamidine acetic acidwith zinc trifluoromethanesulfonate;hydrazine in N,N-dimethyl-formamide at 30; for 36 h;Microwave irradiation;
Stage #2: with hydrogenchloride;sodium nitrite in water;N,N-dimethyl-formamide at 20; pH=3;

References:

Yang, Jun;Karver, Mark R.;Li, Weilong;Sahu, Swagat;Devaraj, Neal K. [Angewandte Chemie - International Edition,2012,vol. 51,# 21,p. 5222 - 5225] Location in patent:supporting information; experimental part

75-09-2 Synthesis