ChemicalBook CAS DataBase List Tirofiban

Tirofiban synthesis

5synthesis methods

Product Name:Tirofiban
CAS Number:144494-65-5
Molecular formula:C22H36N2O5S
Molecular Weight:440.6

N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine

149490-61-9
114 suppliers
$60.00/50 mg

144494-65-5
158 suppliers
$29.00/10mg

Yield:144494-65-5 475 g

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;acetic acid at 60; under 11251.1 Torr; for 6 h;Reagent/catalyst;

Steps:

Compound 6 (500.0 g, 1.1 mol) and 10% palladium on charcoal (25.0 g) was dissolved in acetic acid (5.0 liters, 5% by weight) under the conditions of hydrogen pressure 1.50MPa and stirred at 60 ° C for 6 h. The catalyst was removed by filtration. The filtrate was concentrated to dryness, to the residue was added acetic acid (500 ml) and water (500 ml), stirred for 1 hour ,filtered, a white solid (475.0 g) was obtained. Melting point: 220.0~221.5. The above solid was dissolved in ethyl formate (5.0 liters), a solution of concentrated hydrochloric acid (150 ml) was added dropwise with stirring. After stirring, the mixture was stirred at room temperature for 6 hours.filtered,the filter cake was washed with ethyl acetate and dried under vacuum at 45 ° C for 10 hours to obtain white solid 1 (516.2 g, 95.7%).

References:

HARVEST (HUNAN) PHARMACEUTICAL TECHNOLOGY CO., LTD;YUAN, JINQIAO;CHEN, HE;ZENG, YIHAN;XU, PINGSHENG;YANG, CHANGHUA;XIAO, XIA;LIU, FANGJIE;CHENG, TING;ZHONG, MUYAO;TIAN, JUANNI CN104447509, 2016, B Location in patent:Paragraph 0040-0042

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