trimethyl 2,2',2''-nitrilotribenzoate synthesis
- Product Name:trimethyl 2,2',2''-nitrilotribenzoate
- CAS Number:34069-90-4
- Molecular formula:C24H21NO6
- Molecular Weight:419.43
Yield:34069-90-4 87%
Reaction Conditions:
with copper(l) iodide;copper;potassium carbonate in diphenylether at 190; for 144 h;Inert atmosphere;
Steps:
8.3; 9.3 (3) Synthesis of intermediate 74(3)
Methyl anthranilate (9.0mL, 0.070mol), methyl 2-iodobenzoate (30mL, 0.20mol), K2CO3 (22g, 0.16mol), Cu (0.90g, 14mmol) and CuI (1.3g, 6.8 mmol) was added to the reaction vessel and vacuum dried, and the reaction vessel was filled with nitrogen. Then, diphenyl ether (80 mL) was added thereto, and stirred under reflux at a temperature of 190°C for 6 days. The solvent was removed therefrom under reduced pressure, and the solid thus obtained was dissolved by using EA and methanol. Then, column chromatography was performed on it to obtain Intermediate 74(3) (ie, a yellow solid triester tertiary amine) (22 g, yield 75%).
References:
CN111333615,2020,A Location in patent:Paragraph 0628; 0637-0640; 0657; 0666-0669
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